For unclear factors, leukemia mutations in the RAS gene family preferentially occur in the N-RAS member. A better knowledge of what causes leukemia in children and adults will result in improvements in detection and treatment. Daniel Costa, MD, PhD at Beth Israel Deaconess is analyzing lung cancer patient tumors that develop drug resistance to identify mutations that arise during therapy. The characterization of such mutations will instruction second generation drug development. Ramanuj Dasgupta, PhD at New York University School of Medication, and Naoaki Fujii, PhD at St. Jude Children’s Research Hospital are developing inhibitors as drug candidates by concentrating on different parts of the WNT pathway, aberrations where are connected with an array of tumor types including liver, colon, breast, pancreas, bone, lung, and skin, and with poor prognosis often.‘Our pre-clinical data using the TRAMP mouse model, which mimics human being prostate cancer, shows that calcitriol and QW-1624-F2-2 are promising for avoidance of androgen-dependent prostate tumor progression. Further studies are under way in our laboratory to better know how these agents prevent prostate cancer,’ said Adebusola Alagbala of Roswell Recreation area Cancer Institute and business lead writer of the study. The studies, funded by the National Institutes of Health, were carried out in the laboratory of Dr.