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Human abuse liability studies of the type done by Arena provide essential data to the FDA and DEA for decisions about any post-marketing scheduling and control beneath the Controlled Substance Action, said Edward M. Retailers, M.D., Ph.D., Vice President of Kendle International Inc., and Principal Investigator. Investigational medicines that action through mechanisms in the brain are generally necessary to undergo an evaluation to determine abuse potential. This determination will be made by the US Drug Enforcement Administration , with input from the united states Food and Drug Administration , within the regulatory review procedure.