Trabedersen has been investigated as monotherapy in comparison to current standard therapy with temozolomide ). The results of a earlier randomized, active-controlled Phase IIb study show that the novel, targeted therapy holds significant promise. Recruiting research centers will be published on www Currently.anticancer.de.. Antisense Pharma’s SAPPHIRE Phase III trial evaluating trabedersen approved by Wellness Canada Research to examine trabedersen vs. Current regular chemotherapy in patients with recurrent or refractory anaplastic astrocytoma The biopharmaceutical company Antisense Pharma GmbH has announced today that it has received the authorization by Health Canada for its pivotal Stage III medical trial SAPPHIRE in individuals with recurrent or refractory anaplastic astrocytoma.The end result is the same: eat more fruits and vegetables, says Ronald L. Prior, Ph.D., a chemist and nutritionist with the USDA’s Arkansas Children’s Diet Center in Little Rock, Ark., and lead author of the study. This research confirms that those foods are filled with benefits, those with higher levels of antioxidants particularly. Nuts and spices are great sources also. The brand new study is even more complete and accurate than earlier USDA antioxidant data and includes more foods compared to the previous research, the researchers say. They analyzed antioxidant levels in over 100 different foods, including fruits and vegetables.