However, their severity varies in one individual to another greatly. Moreover, it’s been shown they are more serious among hypertension diabetics and victims. A large level of hyperintensities leads to numerous cerebral problems: cognitive deterioration, increased threat of Alzheimer’s disease, despair, motion disorders and increased threat of stroke. Furthermore, according to many studies, the current presence of a huge quantity of this kind of brain lesion escalates the threat of cognitive deterioration and of Alzheimer’s disease. For this reason the research group coordinated by Christophe Tzourio, director of the Inserm-Universit – Pierre et Marie Curie Mixed Research Device 708 ‘Neuroepidemiology’, advanced the hypothesis that migraines could ‘damage’ the mind.It is very early days, however, and the results should be rigorously tested in clinical studies. A landmark discovery in the past due 1980s by Walter and Eliza Hall Institute researchers that BCL-2 promoted cell survival fuelled more than two decades of global analysis that has culminated in the design of BH3-mimetics. The investigational compound, ABT-199/GDC-0199, was found out by scientists at Abbott and is currently being developed by Genentech, a known member of the Roche group, and AbbVie. Professor Lindeman said he hoped the lately established Centre for Translational Breast Tumor Research could donate to future clinical trials of the novel mixture treatment. Australian ladies who donated their tumour samples for study helped get this to discovery possible, he said.